3 Danny DeVito, The Penguin (Batman Returns, 1992)
Oswald Cobblepot grows up to become a grotesque crime boss after his parents throw the deformed child into the Gotham River and is raised by a flock of penguins. He teams up with business tycoon Max Shreck (Christopher Walken) to take over the city and employs a variety of dark, twisted methods to do it, including murder.
2 Ian McKellan, Magneto (X-Men films, 2000, 2003, 2006, 2014)
The overall role Erik Lehnsherr/Magneto plays as evil to Professor Xavier’s (Patrick Stewart) good is what makes him a great screen supervillain. The two were once friends until Erik came to believe that humans and mutants could never co-exist. Taking his belief to radical extremes, Magneto manipulates metal and uses sophisticated knowledge of genetics to wreak havoc.